Selank
Also referred to as: TP-7, tuftsin analog
A lab-made peptide based on a natural immune fragment, studied in anxiety research. The calm-focused counterpart to Semax.
In plain terms: Selank is a lab-made peptide based on a small natural body fragment, studied mostly for anxiety and calm. It is the sibling compound to Semax (which is studied more for focus and nerve protection). Most research is from Russia and is in animals, with some human studies.
- Name
- Selank
- Aliases
- TP-7, tuftsin analog
- Classification
- Synthetic peptide (tuftsin analog)
- Areas studied
- Anxiety research, Brain messengers, Calm/focus
What it is
Selank is a lab-made peptide based on tuftsin, a small natural fragment of an immune protein, modified to last longer. It is studied mainly in anxiety and stress research.
Like Semax, much of its research comes from Russian institutions. There are some human studies alongside animal work.
Mechanism
In studies, Selank has been linked to the brain's GABA system — the main "calming" signaling system — and to natural calming molecules called enkephalins, which it appears to help protect from being broken down. This is the basis for the anxiety research.
These effects are characterized in animals and some human studies.
Areas studied & investigated
The categories below summarize where Selank appears in the research literature. They describe what the compound is studied for and investigated in — not approved uses, and not guidance for any kind of use.
Anxiety research
Studied for calming effects, compared in some research to standard anti-anxiety drugs.
Brain messengers
Linked to the brain's GABA "calming" system in studies.
Calm & focus
Studied alongside Semax as a calm-leaning counterpart.
Immune-fragment biology
Based on tuftsin, a natural immune-related fragment.
Research history
Selank was developed at the Russian Academy of Sciences from research into tuftsin, as a calm-focused counterpart to Semax. It has a substantial preclinical record and some human anxiety studies.
State of the literature
Selank's research is mostly preclinical with some clinical studies, much of it from Russian groups and not widely repeated elsewhere. It is not an approved drug outside specific countries.
What to keep in mind
As with Semax, much of the Selank research comes from one region and has not been widely confirmed by independent labs — so the evidence is thinner and less verified than it can look. Comparisons to standard anti-anxiety drugs come from small studies. Read the citations and treat the claims as early and not broadly replicated.
Research tools
Evaluating a Selank batch for laboratory research? These free, research-use-only calculators help you work the numbers and read the paperwork: the reconstitution calculator solves vial concentration and draw volume, and the COA reader walks a certificate line by line. For how much and how often Selank is commonly used, see the dosing guides.
Batch-tested with published COAs
See what a published COA looks like
Midwest Compounds does not currently list Selank. Every compound it does sell is tested by an independent lab, with a batch-linked certificate of analysis you can check before you buy.
Citations
The summary above is drawn from published, peer-reviewed sources. Links open the abstract on PubMed, or the free full text on PubMed Central (PMC) where marked.
- Vyunova TV, et al. Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity. Protein & Peptide Letters, 2018. Abstract
- Kasian A, et al. Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats. Behavioural Neurology, 2017. Free full text PMC