GHRP-2
Also referred to as: Pralmorelin, KP-102
A synthetic peptide that prompts growth-hormone release through the ghrelin pathway. Used in research as a pituitary-function test.
In plain terms: GHRP-2 is a lab-made peptide that signals the body to release growth hormone through the ghrelin "door." It has actually been used as a medical test of how well the pituitary gland works. Research is mostly early-stage.
- Name
- GHRP-2
- Aliases
- Pralmorelin, KP-102
- Classification
- Growth-hormone secretagogue (peptide)
- Areas studied
- Ghrelin pathway, Growth hormone & IGF-1, GH secretagogue
What it is
GHRP-2 (also called Pralmorelin) is a synthetic peptide in the growth-hormone secretagogue group. It prompts the body to release its own growth hormone through the ghrelin pathway.
In some countries it has been used as a diagnostic test of pituitary function. Most other research is early-stage.
Mechanism
GHRP-2 plugs into the ghrelin (GHS) docking point to prompt growth-hormone release. It is often studied alongside GHRH-type peptides because the two work through different doors and can be compared or combined in research.
The growth-hormone-to-IGF-1 chain is the downstream system of interest.
Areas studied & investigated
The categories below summarize where GHRP-2 appears in the research literature. They describe what the compound is studied for and investigated in — not approved uses, and not guidance for any kind of use.
Ghrelin pathway
Studied for prompting growth-hormone release through the ghrelin signal.
Growth hormone & IGF-1
Looked at for effects on growth-hormone and IGF-1 levels.
Pituitary testing
Used in some places as a test of how the pituitary responds.
Secretagogue comparison
Compared and sometimes combined with GHRH-type peptides in research.
Research history
GHRP-2 was developed in growth-hormone secretagogue research and has been used as a pituitary-function diagnostic in some countries, alongside a body of pharmacology research.
State of the literature
GHRP-2 has pharmacology and some diagnostic research behind it. Use outside those settings is not established. It is not an approved drug in most markets.
What to keep in mind
The fact that GHRP-2 has been used as a clinical test does not mean general use is supported — a one-time diagnostic dose and ongoing use are very different things. As with all the secretagogues, the broader human evidence is limited. Read the research and keep the diagnostic use separate from the marketing claims.
Research tools
Evaluating a GHRP-2 batch for laboratory research? These free, research-use-only calculators help you work the numbers and read the paperwork: the reconstitution calculator solves vial concentration and draw volume, and the COA reader walks a certificate line by line. For how much and how often GHRP-2 is commonly used, see the dosing guides.
Batch-tested with published COAs
See what a published COA looks like
Midwest Compounds does not currently list GHRP-2. Every compound it does sell is tested by an independent lab, with a batch-linked certificate of analysis you can check before you buy.
Citations
The summary above is drawn from published, peer-reviewed sources. Links open the abstract on PubMed, or the free full text on PubMed Central (PMC) where marked.
- Bowers CY. GH releasing peptides--structure and kinetics. Journal of Pediatric Endocrinology, 1993. Abstract
- Smith RG, et al. Peptidomimetic regulation of growth hormone secretion. Endocrine Reviews, 1997. Abstract